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A sebaceous filament is a tiny collection of sebum and dead skin cells around a hair follicle, which usually takes the form of a small, yellow to off-white hair-like strand when expressed from the skin.cite-ref-whiting-1979-1-0[1]cite-ref-2[2]

These filaments are naturally occurring, and are especially prominent on the nose.cite-ref-3[3]cite-ref-footnoteplewigmelnikwenchieh201964-4-0[4] They are typical among those with naturally oily skin and large pores, even if those individuals have ceased to produce acne.cite-ref-footnoteplewigmelnikwenchieh201964-4-1[4] They are not a sign of infection or any other ailment including acne,cite-ref-footnoteplewigmelnikwenchieh201916-5-0[5] and are commonly mistaken for, though cannot form,cite-ref-footnoteplewigmelnikwenchieh201926-6-0[6] blackheads. Expression, or squeezing, is discouraged as sebaceous filaments are a natural part of healthy human skin. As such, squeezing can lead to unintentional unnecessary harm, such as scarring or inflammation. They help to channel the flow of sebum within a given pore, allowing it to seep gradually to the surface. In 1979, David A. Whiting described them in a review in the Western Journal of Medicine as "a loose, porous mass of horned detritus".cite-ref-whiting-1979-1-1[1]

Sebocytes actively participate in innate immunity by releasing cytokines like IL-1α, IL-6, and TNF-α.cite-ref-7[7]

cite-note-whiting-1979-11. ↑ citerefwhiting1979Whiting, D. A. (1979). "Acne". The Western Journal of Medicine. 131 (6): 551–557. PMC 1271924. PMID 161830.

cite-note-22. ↑ citerefplewigmelnikwenchieh2019Plewig, Gerd; Melnik, Bodo; WenChieh, Chen (2019). Plewig and Kligman's Acne and Rosacea (4th ed.). Basel: Springer Nature Switzerland. p. 2.

cite-note-33. ↑ citerefplewigwolff1976Plewig, Gerd; Wolff, H. H. (1976). "Sebaceous filaments". Archiv für Dermatologische Forschung. 255 (1): 9–21. doi:10.1007/BF00581673. PMID 130839.

cite-note-footnoteplewigmelnikwenchieh201964-44. ↑ Plewig, Melnik & WenChieh (2019), p. 64.

cite-note-footnoteplewigmelnikwenchieh201916-55. ↑ Plewig, Melnik & WenChieh (2019), p. 16.

cite-note-footnoteplewigmelnikwenchieh201926-66. ↑ Plewig, Melnik & WenChieh (2019), p. 26.

cite-note-77. ↑ citerefzoubouliscoenyehekabashima2022Zouboulis, Christos C.; Coenye, Tom; He, Li; Kabashima, Kenji; Kobayashi, Tetsuro; Niemann, Catherin; Nomura, Takashi; Oláh, Attila; Picardo, Mauro; Quist, Sven R.; Sasano, Hironobu; Schneider, Marlon R.; Törőcsik, Daniel; Wong, Sunny Y. (November 10, 2022). "Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations". Frontiers in Immunology. 13. doi:10.3389/fimmu.2022.1029818. PMC 9686445.